IMPACT recommendations

• Details of the major baseline prognostic characteristics should be provided in every report on a TBI study; in trials they should be differentiated per treatment group. We also advocate the reporting of the baseline prognostic risk as determined by validated prognostic models.
• Inclusion criteria should be as broad as is compatible with the current understanding of the mechanisms of action of the intervention being evaluated. This will maximize recruitment rates and enhance the generalisability of the results.
• The statistical analysis should incorporate prespecified covariate adjustment to mitigate the effects of the heterogeneity.
• The statistical analysis should use an ordinal approach, based on either sliding dichotomy or proportional odds methodology.

• IMPACT Recommendations for Improving the Design and Analysis of Clinical Trials in Moderate to Severe Traumatic Brain Injury.
  Maas AI, Steyerberg EW, Marmarou A, McHugh GS, Lingsma HF, Butcher I, Lu J, Weir J, Roozenbeek B, Murray GD.
  Neurotherapeutics. 2010 Jan;7(1):127-134.

• Background
• Mission & Aims
• Collaboration
• Investigators
• Advisory Board
• IMPACT database
• Prognostic calculator
• IMPACT recommendations
• Common Data Elements (Draft)
• Data Sharing
• Acknowledgements

• developed and validated prognostic models for classification and characterization of TBI series
• participated in the development of standardization of data collection in TBI studies (common data elements).
• provided evidence based recommendations for improving sensitivity and efficiency of trials in TBI

• continue its research efforts towards provision of further evidence in support of efforts to improve treatment.
• Advise and assist in the development of clinical research programmes, investigating new treatments for TBI which could lead to better patients outcomes.